According to the replaceWith() documentation:

The .replaceWith() method removes content from the DOM and inserts new
content in its place with a single call.

When an element is removed, as per remove() documentation:

In addition to the elements themselves, all bound events and jQuery
data associated with the elements are removed.

I'm assuming that is why the submit is not executing.

If you want the form to still submit you can manually trigger the submit after you have replaced the element.

DEMO - Submitting the form while replacing the button element

For readability, to demonstrate, I have moved the binding of the click event into script rather than in-line of the element. I also added an id in case of multiple forms, which is not really needed if you only got a single form as you can simply bind to $(form).on(submit) instead then

$(input[name='save']).on(click, function(){

    $(this).replaceWith('<img class=submit-form src=http://www.example.com/images/ajax-loader.gif />');

    $(form).submit();

});



$(#myForm).on(submit, function(){

    alert(form has been submitted.);

    return false;

});

​Edit - Same code using in-line onclick

Moving the code into the in-line onClick still works.

Regarding the form submission, $(this) will be the button before it is replaced and be gone after, hence $(this).closest(form).submit() or any other form of selector using $(this) won't work.

You must target your form for submit neutrally without using $(this) by either using $(form).submit() or if you have mutiple forms use an id as in $(#myForm).submit().

<form id=myForm action=http://jsfiddle.net/>

    <input class=button name=save type=submit onclick=$(this).replaceWith('<img src=http://www.example.com/images/ajax-loader.gif />'); console.log(this); $('#myForm').submit(); value=SUBMIT>

</form>

DEMO - Submitting a form manually after replacing the button using inline onclick

As a side note, if you want the image to be displayed before the submit event is triggered you can apply a little trick like this:

$(input[name='save']).on(click, function(){

    $(this).replaceWith('<img class=submit-form src=http://www.example.com/images/ajax-loader.gif />');



    // Makes sure the image is rendered before the submit executes.

    window.setTimeout(function(){

        $(form).submit();

    }, 300);

});

You can apply the same off course in your in-line onClick.