As others pointed out, there's no built-in JavaScript functions to do that (there are a few high-order functions like map, but not enough for the task). However, some libraries such as Underscore.js provide many utilities to simplify this kind of task.

var totals = _

    .chain(sales) // Wraps up the object in an underscore object,

                  // so methods can be chained

    // First: flatten the sales

    .map(function(v) { 

        return _

            .chain(v)

            .map(function(v2) {

                return v2;

            })

            .value(); 

    })

    .flatten()

    // Second: group the sales by region

    .groupBy('Region')

    // Third: sum the groups and create the object with the totals

    .map(function(g, key) {

        return {

            type: key, 

            val: _(g).reduce(function(m, x) {

                return m + x.Value;

            }, 0)

        };

    })

    .value(); // Unwraps the underscore object back to a plain JS object

Source: this answer at SOpt

This answer assumes the structure of your data is known - contrary to the other answers, which focus on generalizing the structure. Though the code above can be generalized itself, by removing the hardcoded Region and Value and varying the nesting level to something other than two and the aggregation function to something other than sum - as long as the leaves contain both a property you want to group by, and a value you want to aggregate.

function aggregate(object, toGroup, toAggregate, fn, val0) {

    function deepFlatten(x) {

        if ( x[toGroup] !== undefined ) // Leaf

            return x;

        return _.chain(x)

                .map(function(v) { return deepFlatten(v); })

                .flatten()

                .value();

    }



    return _.chain(deepFlatten(object))

            .groupBy(toGroup)

            .map(function(g, key) {

                return {

                    type: key,

                    val: _(g).reduce(function(m, x) {

                        return fn(m, x[toAggregate]);

                    }, val0 || 0)

                };

            })

            .value();

}

It's called like this:

function add(a,b) { return a + b; }

var totals = aggregate(sales, Region, Value, add);

Another example (finds minimum value by region):

function min(a,b) { return a < b ? a : b; }

var mins = aggregate(sales, Region, Value, min, 999999);